Nature Communications (Mar 2023)

Myeloid-associated differentiation marker is an essential host factor for human parechovirus PeV-A3 entry

  • Kanako Watanabe,
  • Tomoichiro Oka,
  • Hirotaka Takagi,
  • Sergei Anisimov,
  • Shun-ichi Yamashita,
  • Yoshinori Katsuragi,
  • Masahiko Takahashi,
  • Masaya Higuchi,
  • Tomotake Kanki,
  • Akihiko Saitoh,
  • Masahiro Fujii

DOI
https://doi.org/10.1038/s41467-023-37399-8
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 14

Abstract

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Human parechovirus genotype A3 (PeV-A3) can cause severe diseases in neonates and young infants. Here, Watanabe et al. identify a host factor myeloid-associated differentiation marker (MYADM) as essential for PeV-A infection and provide evidence for its involvement during virus entry into host cells in vitro.