Intoxication syndrome in patients with pulmonary tuberculosis in relation to the system glutathione transferase gene polymorphism

Abstract

In 178 patients with different clinical forms of pulmonary tuberculosis carried out pharmacogenetic testing to determine gene polymorphism glutathione S-transferase system (GSTM1, GSTT1). Estimated the severity and duration of clinical manifestations of the syndrome of intoxication, depending on the gene polymorphism of glutathione S-transferase system (GSTM1, GSTT1). It was found that the combination of “zero” to develop genotypes GSTM1 and GSTT1 enzyme is a predictor of the severity and duration of symptoms of intoxication persisting.

Keywords

• intoxication
• glutathione s-transferase gene polymorphism
• intoxication. pulmonary tuberculosis