Nature Communications (Dec 2021)
Glucocorticoid receptor regulates PD-L1 and MHC-I in pancreatic cancer cells to promote immune evasion and immunotherapy resistance
- Yalan Deng,
- Xianghou Xia,
- Yang Zhao,
- Zilong Zhao,
- Consuelo Martinez,
- Wenjuan Yin,
- Jun Yao,
- Qinglei Hang,
- Weiche Wu,
- Jie Zhang,
- Yang Yu,
- Weiya Xia,
- Fan Yao,
- Di Zhao,
- Yutong Sun,
- Haoqiang Ying,
- Mien-Chie Hung,
- Li Ma
Affiliations
- Yalan Deng
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Xianghou Xia
- Department of Breast Surgery, Zhejiang Cancer Hospital, Institute of Cancer and Basic Medicine, Chinese Academy of Sciences
- Yang Zhao
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Zilong Zhao
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Consuelo Martinez
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Wenjuan Yin
- Department of Pathology, Zhejiang Cancer Hospital, Institute of Cancer and Basic Medicine, Chinese Academy of Sciences
- Jun Yao
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Qinglei Hang
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Weiche Wu
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Jie Zhang
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Yang Yu
- Department of Breast Surgery, Zhejiang Cancer Hospital, Institute of Cancer and Basic Medicine, Chinese Academy of Sciences
- Weiya Xia
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Fan Yao
- Hubei Hongshan Laboratory, College of Life Science and Technology, College of Biomedicine and Health, Huazhong Agricultural University
- Di Zhao
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Yutong Sun
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Haoqiang Ying
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Mien-Chie Hung
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Li Ma
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- DOI
- https://doi.org/10.1038/s41467-021-27349-7
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
Glucocorticoids and glucocorticoid receptor (GR) signalling can suppress anti-tumour immunity. Here the authors show that GR activates PD-L1 expression and represses MHC-I expression in pancreatic cancer cells, while GR inhibition enhances anti-tumour immunity and sensitises the cancer cells to immunotherapy.
