LDLR, LRP1, and Megalin redundantly participate in the uptake of Clostridium novyi alpha-toxin

Yao Zhou; Danyang Li; Diyin Li; Aizhong Chen; Liuqing He; Jianhua Luo; Liang Tao

doi:10.1038/s42003-022-03873-0

Communications Biology (Sep 2022)

LDLR, LRP1, and Megalin redundantly participate in the uptake of Clostridium novyi alpha-toxin

Yao Zhou,
Danyang Li,
Diyin Li,
Aizhong Chen,
Liuqing He,
Jianhua Luo,
Liang Tao

Affiliations

Yao Zhou: College of Life Sciences, Zhejiang University
Danyang Li: College of Life Sciences, Zhejiang University
Diyin Li: College of Life Sciences, Zhejiang University
Aizhong Chen: Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University
Liuqing He: Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University
Jianhua Luo: Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University
Liang Tao: College of Life Sciences, Zhejiang University

DOI: https://doi.org/10.1038/s42003-022-03873-0
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 9

Abstract

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Clostridium novyi alpha-toxin (Tcnα) also uses LRP1 and Megalin as cellular entry receptors besides LDLR, and this might be a response to cell-type dependent receptor availability for the exotoxin.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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