Nature Communications (Sep 2018)
Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis
- Grigory Ryzhakov,
- Nathaniel R. West,
- Fanny Franchini,
- Simon Clare,
- Nicholas E. Ilott,
- Stephen N. Sansom,
- Samuel J. Bullers,
- Claire Pearson,
- Alice Costain,
- Alun Vaughan-Jackson,
- Jeremy A. Goettel,
- Joerg Ermann,
- Bruce H. Horwitz,
- Ludovico Buti,
- Xin Lu,
- Subhankar Mukhopadhyay,
- Scott B. Snapper,
- Fiona Powrie
Affiliations
- Grigory Ryzhakov
- Kennedy Institute of Rheumatology, University of Oxford
- Nathaniel R. West
- Kennedy Institute of Rheumatology, University of Oxford
- Fanny Franchini
- Kennedy Institute of Rheumatology, University of Oxford
- Simon Clare
- Wellcome Trust Sanger Institute, Hinxton
- Nicholas E. Ilott
- Kennedy Institute of Rheumatology, University of Oxford
- Stephen N. Sansom
- Kennedy Institute of Rheumatology, University of Oxford
- Samuel J. Bullers
- Kennedy Institute of Rheumatology, University of Oxford
- Claire Pearson
- Kennedy Institute of Rheumatology, University of Oxford
- Alice Costain
- Kennedy Institute of Rheumatology, University of Oxford
- Alun Vaughan-Jackson
- Kennedy Institute of Rheumatology, University of Oxford
- Jeremy A. Goettel
- Boston Children’s Hospital and Harvard Medical School
- Joerg Ermann
- Department of Gastroenterology, Brigham and Women’s Hospital and Harvard Medical School
- Bruce H. Horwitz
- Department of Gastroenterology, Brigham and Women’s Hospital and Harvard Medical School
- Ludovico Buti
- Ludwig Institute of Cancer Research, University of Oxford
- Xin Lu
- Ludwig Institute of Cancer Research, University of Oxford
- Subhankar Mukhopadhyay
- Wellcome Trust Sanger Institute, Hinxton
- Scott B. Snapper
- Boston Children’s Hospital and Harvard Medical School
- Fiona Powrie
- Kennedy Institute of Rheumatology, University of Oxford
- DOI
- https://doi.org/10.1038/s41467-018-06085-5
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
The Hiccs locus has been associated with susceptibility to colitis in mice. Here the authors identify a Hiccs locus gene encoding Alpha kinase 1 as a potent regulator of intestinal inflammation via modulation of the IL-12/Th1 axis.
