Nature Communications (Sep 2018)

Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis

  • Grigory Ryzhakov,
  • Nathaniel R. West,
  • Fanny Franchini,
  • Simon Clare,
  • Nicholas E. Ilott,
  • Stephen N. Sansom,
  • Samuel J. Bullers,
  • Claire Pearson,
  • Alice Costain,
  • Alun Vaughan-Jackson,
  • Jeremy A. Goettel,
  • Joerg Ermann,
  • Bruce H. Horwitz,
  • Ludovico Buti,
  • Xin Lu,
  • Subhankar Mukhopadhyay,
  • Scott B. Snapper,
  • Fiona Powrie

DOI
https://doi.org/10.1038/s41467-018-06085-5
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 13

Abstract

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The Hiccs locus has been associated with susceptibility to colitis in mice. Here the authors identify a Hiccs locus gene encoding Alpha kinase 1 as a potent regulator of intestinal inflammation via modulation of the IL-12/Th1 axis.