Nature Communications (Mar 2019)

Enhanced antibiotic resistance development from fluoroquinolone persisters after a single exposure to antibiotic

  • Theresa C. Barrett,
  • Wendy W. K. Mok,
  • Allison M. Murawski,
  • Mark P. Brynildsen

DOI
https://doi.org/10.1038/s41467-019-09058-4
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 11

Abstract

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Fluoroquinolone (FQ)-induced DNA damage in persisters could promote antibiotic resistance. Here, using time-lapse microscopy and genetic analyses, the authors show that after a single round of FQ treatment, SOS response in persisters accelerates the development of resistance to unrelated antibiotics.