CLINICAL PROFILE OF INVASIVE PNEUMOCOCCAL DISEASES AT CHILDREN IN UZBEKISTAN

Abstract

From January 2008 to December 2013, a study was conducted of children patients (between the ages of 3 months to 14 years) with purulent meningitis (n = 210) and pneumonia (n = 265) admitted to specialized hospitals of Tashkent city. The material for the study were the blood, cerebrospinal fluid, pleural fluid. Of the 210 patients with purulent meningitis 98 (46.6%) cultures of S. pneumoniae were isolated, of 265 patients with pneumonia 37 (13.9%) cultures of S. pneumoniae were isolated (33 strains from the blood, 4 strains from pleural fluids). It has been found that there is a high sensitivity of the isolates of S. pneumoniae (94.8%) to penicillin. It is recommended to rationally use macrolides in the treatment of invasive pneumococcal diseases in children, given the spread of strains of S.pneumoniae, resistant to the drugs of these group. Identified pneumococcal serotypes are included in the pneumococcal vaccines, which quite justifies the need to introduce preventive vaccination in the schedule of vaccination of children against pneumococcal diseases in the Republic of Uzbekistan.

Keywords

• invasive pneumococcal diseases
• pneumococci
• serotypes
• antibacterial susceptibility
• children