COVID-19 and NSTEMI Outcomes among Hospitalized Patients in the United States and Racial Disparities in Mortality: Insight from National Inpatient Sample Database

Harris Majeed; Karthik Gangu; Shazib Sagheer; Ishan Garg; Umair Khan; Hina Shuja; Aniesh Bobba; Prabal Chourasia; Rahul Shekhar; Sindhu Reddy Avula; Abu Baker Sheikh

doi:10.3390/vaccines10122024

Vaccines (Nov 2022)

COVID-19 and NSTEMI Outcomes among Hospitalized Patients in the United States and Racial Disparities in Mortality: Insight from National Inpatient Sample Database

Harris Majeed,
Karthik Gangu,
Shazib Sagheer,
Ishan Garg,
Umair Khan,
Hina Shuja,
Aniesh Bobba,
Prabal Chourasia,
Rahul Shekhar,
Sindhu Reddy Avula,
Abu Baker Sheikh

Affiliations

Harris Majeed: Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87106, USA
Karthik Gangu: Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS 66103, USA
Shazib Sagheer: Division of Cardiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87106, USA
Ishan Garg: Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87106, USA
Umair Khan: Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87106, USA
Hina Shuja: Department of Medicine, Karachi Medical and Dental College, Karachi 74700, Pakistan
Aniesh Bobba: Department of Medicine, John H. Stronger Hospital, Cook County, Chicago, IL 60612, USA
Prabal Chourasia: Division of Hospital Medicine, Mary Washington Hospital, Fredericksburg, VA 22401, USA
Rahul Shekhar: Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87106, USA
Sindhu Reddy Avula: Department of Interventional Cardiology, Division of Cardiology, University of Kansas, St. Francis Campus, Kansas City, KS 66606, USA
Abu Baker Sheikh: Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87106, USA

DOI: https://doi.org/10.3390/vaccines10122024
Journal volume & issue: Vol. 10, no. 12
p. 2024

Abstract

Read online

The COVID-19 pandemic has impacted healthcare delivery to patients with non-ST-segment elevation myocardial infraction (NSTEMI). The aim of our retrospective study is to determine the effect of COVID-19 on inpatient NSTEMI outcomes and to investigate whether changes in cardiac care contributed to the observed outcomes. After multivariate adjustment, we found that NSTEMI patients with COVID-19 had a higher rate of inpatient mortality (37.3% vs. 7.3%, adjusted odds ratio: 4.96, 95% CI: 4.6–5.4, p p p p p p < 0.001). In our study, we observed increased mortality and in-hospital complications to be a combined effect of COVID-19 infection and myocardial inflammation as a result of cytokine storm, prothrombic state, oxygen supply/demand imbalance and alterations in healthcare delivery from January to December 2020.

Published in Vaccines

ISSN: 2076-393X (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine
Website: http://www.mdpi.com/journal/vaccines

About the journal

Abstract

Keywords