Zuo1 supports G4 structure formation and directs repair toward nucleotide excision repair

Alessio De Magis; Silvia Götz; Mona Hajikazemi; Enikő Fekete-Szücs; Marco Caterino; Stefan Juranek; Katrin Paeschke

doi:10.1038/s41467-020-17701-8

Nature Communications (Aug 2020)

Zuo1 supports G4 structure formation and directs repair toward nucleotide excision repair

Alessio De Magis,
Silvia Götz,
Mona Hajikazemi,
Enikő Fekete-Szücs,
Marco Caterino,
Stefan Juranek,
Katrin Paeschke

Affiliations

Alessio De Magis: Department of Oncology, Hematology and Rheumatology, University Hospital Bonn
Silvia Götz: Department of Biochemistry, Biocenter, University of Würzburg
Mona Hajikazemi: Department of Oncology, Hematology and Rheumatology, University Hospital Bonn
Enikő Fekete-Szücs: European Research Institute for the Biology of Ageing, University of Groningen
Marco Caterino: Department of Oncology, Hematology and Rheumatology, University Hospital Bonn
Stefan Juranek: Department of Oncology, Hematology and Rheumatology, University Hospital Bonn
Katrin Paeschke: Department of Oncology, Hematology and Rheumatology, University Hospital Bonn

DOI: https://doi.org/10.1038/s41467-020-17701-8
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 12

Abstract

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G4 structure-interacting proteins have been linked to DNA repair processes. Here the authors reveal that in yeast, Zuo1 associates with G4 structures and plays a role in repair pathway choice by promoting nucleotide excision repair and ultimately contributing to maintenance of genome stability.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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