Function Identification in Neuron Populations via Information Bottleneck

Abstract

It is plausible to hypothesize that the spiking responses of certain neurons represent functions of the spiking signals of other neurons. A natural ensuing question concerns how to use experimental data to infer what kind of a function is being computed. Model-based approaches typically require assumptions on how information is represented. By contrast, information measures are sensitive only to relative behavior: information is unchanged by applying arbitrary invertible transformations to the involved random variables. This paper develops an approach based on the information bottleneck method that attempts to find such functional relationships in a neuron population. Specifically, the information bottleneck method is used to provide appropriate compact representations which can then be parsed to infer functional relationships. In the present paper, the parsing step is specialized to the case of remapped-linear functions. The approach is validated on artificial data and then applied to recordings from the motor cortex of a macaque monkey performing an arm-reaching task. Functional relationships are identified and shown to exhibit some degree of persistence across multiple trials of the same experiment.

Keywords

• information theory
• information bottleneck method
• neuroscience