Delayed Behavioral Effects of SH–I–048A, a Novel Nonselective Positive Modulator of Gabaa Receptors, After Peripheral Nerve Injury in Rats

Obradović Lj. Aleksandar; Joksimović Srđan; M. Poe Michael; Timić Tamara; M.Cook  James; M. Savić  Miroslav

doi:10.2478/acve-2014-0018

Acta Veterinaria (Jun 2014)

Delayed Behavioral Effects of SH–I–048A, a Novel Nonselective Positive Modulator of Gabaa Receptors, After Peripheral Nerve Injury in Rats

Obradović Lj. Aleksandar,
Joksimović Srđan,
M. Poe Michael,
Timić Tamara,
M.Cook James,
M. Savić Miroslav

Affiliations

Obradović Lj. Aleksandar: Department of Physiology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
Joksimović Srđan: Department of Pharmacology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
M. Poe Michael: Department of Chemistry and Biochemistry, University of Wisconsin–Milwaukee, Milwaukee, Wisconsin, USA
Timić Tamara: Department of Pharmacology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
M.Cook James: Department of Chemistry and Biochemistry, University of Wisconsin–Milwaukee, Milwaukee, Wisconsin, USA
M. Savić Miroslav: Department of Pharmacology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia

DOI: https://doi.org/10.2478/acve-2014-0018
Journal volume & issue: Vol. 64, no. 2
pp. 189 – 199

Abstract

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Kompleksna klinička slika neuropatije nakon povrede perifernog nerva često je praćena i promenama afektivnog stanja pacijenata. U animalnim modelima bola pokazano je da pozitivni alosterni modulatori GABAA receptora mogu da smanje nociceptivnu transmisiju. Međutim, skorašnji nalazi ukazuju i na mogućnost da je prividni antinociceptivni efekat benzodiazepina nakon delovanja akutnog bolnog stimulusa u značajnoj meri posledica anksiolitičnog efekta.

Published in Acta Veterinaria

ISSN: 1820-7448 (Online)
Publisher: Sciendo
Country of publisher: Serbia
LCC subjects: Agriculture: Animal culture: Veterinary medicine
Website: https://sciendo.com/journal/ACVE

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