Communications Biology (Jan 2022)

Maternal diabetes-mediated RORA suppression in mice contributes to autism-like offspring through inhibition of aromatase

  • Hong Yu,
  • Yanbin Niu,
  • Guohua Jia,
  • Yujie Liang,
  • Baolin Chen,
  • Ruoyu Sun,
  • Min Wang,
  • Saijun Huang,
  • Jiaying Zeng,
  • Jianpin Lu,
  • Ling Li,
  • Xiaoling Guo,
  • Paul Yao

DOI
https://doi.org/10.1038/s42003-022-03005-8
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 16

Abstract

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Hong Yu, Yanbin Niu, Guohua Jia et al. integrate in vitro, in vivo, and human experiments to examine a link between RORA expression on autism-like behavior. Their results suggest that maternal diabetes may contribute to autism-like behavior via RORA suppression.