Nature Communications (May 2021)

Mapping the molecular and structural specialization of the skin basement membrane for inter-tissue interactions

  • Ko Tsutsui,
  • Hiroki Machida,
  • Asako Nakagawa,
  • Kyungmin Ahn,
  • Ritsuko Morita,
  • Kiyotoshi Sekiguchi,
  • Jeffrey H. Miner,
  • Hironobu Fujiwara

DOI
https://doi.org/10.1038/s41467-021-22881-y
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 18

Abstract

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The basement membrane is located at tissue interfaces, but how it mediates distinct inter-tissue interactions is unclear. Here, the authors systematically define the spatial heterogeneity of skin basement membrane composition and show its functional importance in inter-tissue interactions.