Chinese Journal of Lung Cancer (May 2009)
The Expression and Significance of Annexin Ⅱ in Lung Squamous Cell Cancer and Adenocarcinom
Abstract
Background and objective Annexin Ⅱ is a calcium-dependent phosphnolipid-binding proteinthat plays a role in many cellular functions. It has been proven that annexin Ⅱ has been involved in many human cancers.The aim of this study is to examine the expression of annexin Ⅱ in lung cancer tissues, and analyze the correlationsbetween annexin Ⅱ and clinicopathological parameters. Methods Annexin Ⅱ expression was examined in 110 lungcancer specimens using immunohistochemistry (SP method). Western Blot was used to detect the expression of annexin Ⅱin lung cancer tissues and the corresponding normal lung tissues. Results Among 110 lung cancer specimens, 67 samplesshowed positive expression of annexin Ⅱ (60.9%). It showed membranous staining in lung squamous cell carcinoma.The positive membranous expression and cytoplasmic expression of annexin Ⅱ in lung adenocarcinoma mainly showedmembranous staining. Annexin Ⅱ expression level was positively correlated with lymphoid node metastasis (P =0.008)and TNM stages (P =0.002). There was expression of annexin Ⅱ in both lung cancer tissues and the corresponding normallung tissues, and in lung cancer tissues, the total levels of annexin Ⅱ proteins were significantly higher than that in thecorresponding normal lung tissues (P <0.001). Conclusion The expression of annexin Ⅱ positively may correlated withlung squamous cell carcinoma and adenocarcinoma development.
