Cu/Fe MAGNETIC NANOPARTICLES WITH ANTITUMOR ACTIVITY

Abstract

The use of bimetallic nanoparticles of biocompatible metals with magnetic properties is a new approach to combating cancer cells. Nanoparticles of immiscible Fe/Cu metals, with separated phases at the level of one particle, were synthesized by electric explosion of iron and copper wires in an argon atmosphere. To characterize Cu/Fe nanoparticles, X-ray phase analysis, transmission electron microscopy, thermal desorption of nitrogen, and energy-dispersive analysis were used. Our research has shown that synthesized nanoparticles have antitumor activity against Neuro 2A and J 774 cell lines. Such particles may be promising for the development of drugs for magnetic target delivery.

Keywords

• magnetic nanoparticles
• electric explosion of metal conductors
• core-shell structure
• segregated structure
• mtt test
• tumor cells