Determinants of synapse diversity revealed by super-resolution quantal transmission and active zone imaging

Zachary L. Newman; Dariya Bakshinskaya; Ryan Schultz; Samuel J. Kenny; Seonah Moon; Krisha Aghi; Cherise Stanley; Nadia Marnani; Rachel Li; Julia Bleier; Ke Xu; Ehud Y. Isacoff

doi:10.1038/s41467-021-27815-2

Nature Communications (Jan 2022)

Determinants of synapse diversity revealed by super-resolution quantal transmission and active zone imaging

Zachary L. Newman,
Dariya Bakshinskaya,
Ryan Schultz,
Samuel J. Kenny,
Seonah Moon,
Krisha Aghi,
Cherise Stanley,
Nadia Marnani,
Rachel Li,
Julia Bleier,
Ke Xu,
Ehud Y. Isacoff

Affiliations

Zachary L. Newman: Department of Molecular and Cell Biology, University of California Berkeley
Dariya Bakshinskaya: Helen Wills Neuroscience Institute, University of California Berkeley
Ryan Schultz: Helen Wills Neuroscience Institute, University of California Berkeley
Samuel J. Kenny: Department of Chemistry, University of California
Seonah Moon: Department of Chemistry, University of California
Krisha Aghi: Helen Wills Neuroscience Institute, University of California Berkeley
Cherise Stanley: Department of Molecular and Cell Biology, University of California Berkeley
Nadia Marnani: Department of Molecular and Cell Biology, University of California Berkeley
Rachel Li: Department of Molecular and Cell Biology, University of California Berkeley
Julia Bleier: Helen Wills Neuroscience Institute, University of California Berkeley
Ke Xu: Department of Molecular and Cell Biology, University of California Berkeley
Ehud Y. Isacoff: Department of Molecular and Cell Biology, University of California Berkeley

DOI: https://doi.org/10.1038/s41467-021-27815-2
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 18

Abstract

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Super-resolution quantal imaging relates transmission at excitatory synapses to presynaptic molecular composition. The authors find that evoked transmission varies greatly between synapses and is uncorrelated and physically separate from spontaneous transmission, and identify responsible presynaptic proteins.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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