Nature Communications (Jul 2022)
A third vaccination with a single T cell epitope confers protection in a murine model of SARS-CoV-2 infection
- Iris N. Pardieck,
- Tetje C. van der Sluis,
- Esmé T. I. van der Gracht,
- Dominique M. B. Veerkamp,
- Felix M. Behr,
- Suzanne van Duikeren,
- Guillaume Beyrend,
- Jasper Rip,
- Reza Nadafi,
- Elham Beyranvand Nejad,
- Nils Mülling,
- Dena J. Brasem,
- Marcel G. M. Camps,
- Sebenzile K. Myeni,
- Peter J. Bredenbeek,
- Marjolein Kikkert,
- Yeonsu Kim,
- Luka Cicin-Sain,
- Tamim Abdelaal,
- Klaas P. J. M. van Gisbergen,
- Kees L. M. C. Franken,
- Jan Wouter Drijfhout,
- Cornelis J. M. Melief,
- Gerben C. M. Zondag,
- Ferry Ossendorp,
- Ramon Arens
Affiliations
- Iris N. Pardieck
- Department of Immunology, Leiden University Medical Center
- Tetje C. van der Sluis
- Department of Immunology, Leiden University Medical Center
- Esmé T. I. van der Gracht
- Department of Immunology, Leiden University Medical Center
- Dominique M. B. Veerkamp
- Department of Immunology, Leiden University Medical Center
- Felix M. Behr
- Department of Immunology, Leiden University Medical Center
- Suzanne van Duikeren
- Department of Immunology, Leiden University Medical Center
- Guillaume Beyrend
- Department of Immunology, Leiden University Medical Center
- Jasper Rip
- Department of Immunology, Leiden University Medical Center
- Reza Nadafi
- Department of Immunology, Leiden University Medical Center
- Elham Beyranvand Nejad
- Department of Immunology, Leiden University Medical Center
- Nils Mülling
- Department of Immunology, Leiden University Medical Center
- Dena J. Brasem
- Department of Immunology, Leiden University Medical Center
- Marcel G. M. Camps
- Department of Immunology, Leiden University Medical Center
- Sebenzile K. Myeni
- Department of Medical Microbiology, Leiden University Medical Center
- Peter J. Bredenbeek
- Department of Medical Microbiology, Leiden University Medical Center
- Marjolein Kikkert
- Department of Medical Microbiology, Leiden University Medical Center
- Yeonsu Kim
- Department of Viral Immunology, Helmholtz Centre for Infection Research
- Luka Cicin-Sain
- Department of Viral Immunology, Helmholtz Centre for Infection Research
- Tamim Abdelaal
- Delft Bioinformatics Lab, Delft University of Technology
- Klaas P. J. M. van Gisbergen
- Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory
- Kees L. M. C. Franken
- Department of Immunology, Leiden University Medical Center
- Jan Wouter Drijfhout
- Department of Immunology, Leiden University Medical Center
- Cornelis J. M. Melief
- ISA Pharmaceuticals BV
- Gerben C. M. Zondag
- Immunetune BV
- Ferry Ossendorp
- Department of Immunology, Leiden University Medical Center
- Ramon Arens
- Department of Immunology, Leiden University Medical Center
- DOI
- https://doi.org/10.1038/s41467-022-31721-6
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 11
Abstract
Vaccination regimens and the number of doses required for optimal immunity and protection are critical factors in the translation of vaccines. Here the authors show administration of a three dose protocol of a single T cell epitope to the SARS-CoV-2 spike protein induces a robust CD8+ T cell response and confers protection in a lethal murine challenge model of infection.
