Nature Communications (Oct 2021)
ChAdOx1 nCoV-19 (AZD1222) protects Syrian hamsters against SARS-CoV-2 B.1.351 and B.1.1.7
- Robert J. Fischer,
- Neeltje van Doremalen,
- Danielle R. Adney,
- Claude Kwe Yinda,
- Julia R. Port,
- Myndi G. Holbrook,
- Jonathan E. Schulz,
- Brandi N. Williamson,
- Tina Thomas,
- Kent Barbian,
- Sarah L. Anzick,
- Stacy Ricklefs,
- Brian J. Smith,
- Dan Long,
- Craig Martens,
- Greg Saturday,
- Emmie de Wit,
- Sarah C. Gilbert,
- Teresa Lambe,
- Vincent J. Munster
Affiliations
- Robert J. Fischer
- Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Neeltje van Doremalen
- Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Danielle R. Adney
- Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Claude Kwe Yinda
- Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Julia R. Port
- Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Myndi G. Holbrook
- Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Jonathan E. Schulz
- Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Brandi N. Williamson
- Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Tina Thomas
- Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Kent Barbian
- Research Technologies Branch, Rocky Mountain Laboratories, National Institutes of Health
- Sarah L. Anzick
- Research Technologies Branch, Rocky Mountain Laboratories, National Institutes of Health
- Stacy Ricklefs
- Research Technologies Branch, Rocky Mountain Laboratories, National Institutes of Health
- Brian J. Smith
- Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Dan Long
- Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Craig Martens
- Research Technologies Branch, Rocky Mountain Laboratories, National Institutes of Health
- Greg Saturday
- Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Emmie de Wit
- Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Sarah C. Gilbert
- The Jenner Institute, Nuffield Department of Medicine, University of Oxford
- Teresa Lambe
- The Jenner Institute, Nuffield Department of Medicine, University of Oxford
- Vincent J. Munster
- Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- DOI
- https://doi.org/10.1038/s41467-021-26178-y
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 11
Abstract
Emerging SARS-CoV-2 variants raise concerns about vaccine effectiveness. Here, the authors show that the ChAdOx1 nCoV-19 (AZD1222) vaccine protects Syrian hamsters from pulmonary infection and disease after infection with SARS-CoV-2 B.1.351 or B.1.1.7 variants.
