Nature Communications (Oct 2019)

ZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer

  • Arun Kanakkanthara,
  • Catherine J. Huntoon,
  • Xiaonan Hou,
  • Minzhi Zhang,
  • Ethan P. Heinzen,
  • Daniel R. O’Brien,
  • Ann L. Oberg,
  • S. John Weroha,
  • Scott H. Kaufmann,
  • Larry M. Karnitz

DOI
https://doi.org/10.1038/s41467-019-12610-x
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 15

Abstract

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High-grade serous ovarian cancers (HGSOCs) have defects in homologous recombination despite a lack of BRCA1/2 mutations. Here, the authors show that ZC3H18 positively regulates BRCA1 transcription and its loss causes BRCA1 promoter methylation and increased HR deficiency in HGSOCs.