Nature Communications (Nov 2020)
Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies methylation changes in AHRR
- Alicia K. Smith,
- Andrew Ratanatharathorn,
- Adam X. Maihofer,
- Robert K. Naviaux,
- Allison E. Aiello,
- Ananda B. Amstadter,
- Allison E. Ashley-Koch,
- Dewleen G. Baker,
- Jean C. Beckham,
- Marco P. Boks,
- Evelyn Bromet,
- Michelle Dennis,
- Sandro Galea,
- Melanie E. Garrett,
- Elbert Geuze,
- Guia Guffanti,
- Michael A. Hauser,
- Seyma Katrinli,
- Varun Kilaru,
- Ronald C. Kessler,
- Nathan A. Kimbrel,
- Karestan C. Koenen,
- Pei-Fen Kuan,
- Kefeng Li,
- Mark W. Logue,
- Adriana Lori,
- Benjamin J. Luft,
- Mark W. Miller,
- Jane C. Naviaux,
- Nicole R. Nugent,
- Xuejun Qin,
- Kerry J. Ressler,
- Victoria B. Risbrough,
- Bart P. F. Rutten,
- Murray B. Stein,
- Robert J. Ursano,
- Eric Vermetten,
- Christiaan H. Vinkers,
- Lin Wang,
- Nagy A. Youssef,
- INTRuST Clinical Consortium,
- VA Mid-Atlantic MIRECC Workgroup,
- PGC PTSD Epigenetics Workgroup,
- Monica Uddin,
- Caroline M. Nievergelt
Affiliations
- Alicia K. Smith
- Emory University, Department of Gynecology and Obstetrics
- Andrew Ratanatharathorn
- Columbia University, Department of Epidemiology
- Adam X. Maihofer
- University of California San Diego, Department of Psychiatry
- Robert K. Naviaux
- University of California, The Mitochondrial and Metabolic Disease Center, Departments of Medicine, Pediatrics, and Pathology
- Allison E. Aiello
- University of North Carolina, Gillings School of Global Public Health, Department of Epidemiology
- Ananda B. Amstadter
- Virginia Commonwealth University, Department of Psychiatry
- Allison E. Ashley-Koch
- Duke Molecular Physiology Institute, Duke University Medical Center
- Dewleen G. Baker
- University of California San Diego, Department of Psychiatry
- Jean C. Beckham
- VA Mid-Atlantic, Mental Illness Research, Education, and Clinical Center
- Marco P. Boks
- University Medical Center Utrecht, Brain Center Rudolf Magnus
- Evelyn Bromet
- State University of New York at Stony Brook, Epidemiology Research Group
- Michelle Dennis
- VA Mid-Atlantic, Mental Illness Research, Education, and Clinical Center
- Sandro Galea
- Boston University, School of Public Health
- Melanie E. Garrett
- Duke Molecular Physiology Institute, Duke University Medical Center
- Elbert Geuze
- University Medical Center Utrecht, Brain Center Rudolf Magnus
- Guia Guffanti
- McLean Hospital, Division of Depression and Anxiety
- Michael A. Hauser
- Duke Molecular Physiology Institute, Duke University Medical Center
- Seyma Katrinli
- Emory University, Department of Gynecology and Obstetrics
- Varun Kilaru
- Emory University, Department of Gynecology and Obstetrics
- Ronald C. Kessler
- Harvard Medical School
- Nathan A. Kimbrel
- VA Mid-Atlantic, Mental Illness Research, Education, and Clinical Center
- Karestan C. Koenen
- Harvard T.H. Chan School of Public Health, Department of Epidemiology
- Pei-Fen Kuan
- State University of New York at Stony Brook, Department of Applied Mathematics and Statistics
- Kefeng Li
- University of California, The Mitochondrial and Metabolic Disease Center, Department of Medicine
- Mark W. Logue
- National Center for PTSD, Behavioral Science Division at VA Boston Healthcare System
- Adriana Lori
- Emory University, Department of Psychiatry & Behavioral Sciences
- Benjamin J. Luft
- State University of New York at Stony Brook, Department of Medicine
- Mark W. Miller
- National Center for PTSD, Behavioral Science Division at VA Boston Healthcare System
- Jane C. Naviaux
- University of California, The Mitochondrial and Metabolic Disease Center, Department of Neuroscience
- Nicole R. Nugent
- Brown University, Psychiatry and Human Behavior, Department of Pediatric Research
- Xuejun Qin
- Duke Molecular Physiology Institute, Duke University Medical Center
- Kerry J. Ressler
- Emory University, Department of Psychiatry & Behavioral Sciences
- Victoria B. Risbrough
- University of California San Diego, Department of Psychiatry
- Bart P. F. Rutten
- Maastricht University Medical Centre, School for Mental Health and Neuroscience, Department of Psychiatry and Neuropsychology
- Murray B. Stein
- University of California San Diego, Department of Psychiatry
- Robert J. Ursano
- Uniformed Services University School of Medicine, Center for the Study of Traumatic Stress
- Eric Vermetten
- University Medical Center Utrecht, Brain Center Rudolf Magnus
- Christiaan H. Vinkers
- Amsterdam UMC (location VUmc), Department of Psychiatry
- Lin Wang
- University of California, The Mitochondrial and Metabolic Disease Center, Department of Medicine
- Nagy A. Youssef
- Medical College of Georgia at Augusta University, Department of Psychiatry and Human Behavior and Office of Academic Affairs
- INTRuST Clinical Consortium
- VA Mid-Atlantic MIRECC Workgroup
- PGC PTSD Epigenetics Workgroup
- Monica Uddin
- University of South Florida, College of Public Health
- Caroline M. Nievergelt
- University of California San Diego, Department of Psychiatry
- DOI
- https://doi.org/10.1038/s41467-020-19615-x
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 9
Abstract
PTSD has been associated with DNA methylation of specific loci in the genome, but studies have been limited by small sample sizes. Here, the authors perform a meta-analysis of DNA methylation data from 10 different cohorts and identify CpGs in AHRR that are associated with PTSD.
