Vaccines (May 2024)
Virological Traits of the SARS-CoV-2 BA.2.87.1 Lineage
- Lu Zhang,
- Alexandra Dopfer-Jablonka,
- Inga Nehlmeier,
- Amy Kempf,
- Luise Graichen,
- Noemí Calderón Hampel,
- Anne Cossmann,
- Metodi V. Stankov,
- Gema Morillas Ramos,
- Sebastian R. Schulz,
- Hans-Martin Jäck,
- Georg M. N. Behrens,
- Stefan Pöhlmann,
- Markus Hoffmann
Affiliations
- Lu Zhang
- Infection Biology Unit, German Primate Center—Leibniz Institute for Primate Research, 37077 Göttingen, Germany
- Alexandra Dopfer-Jablonka
- Department of Rheumatology and Immunology, Hannover Medical School, 30625 Hannover, Germany
- Inga Nehlmeier
- Infection Biology Unit, German Primate Center—Leibniz Institute for Primate Research, 37077 Göttingen, Germany
- Amy Kempf
- Infection Biology Unit, German Primate Center—Leibniz Institute for Primate Research, 37077 Göttingen, Germany
- Luise Graichen
- Infection Biology Unit, German Primate Center—Leibniz Institute for Primate Research, 37077 Göttingen, Germany
- Noemí Calderón Hampel
- Department of Rheumatology and Immunology, Hannover Medical School, 30625 Hannover, Germany
- Anne Cossmann
- Department of Rheumatology and Immunology, Hannover Medical School, 30625 Hannover, Germany
- Metodi V. Stankov
- Department of Rheumatology and Immunology, Hannover Medical School, 30625 Hannover, Germany
- Gema Morillas Ramos
- Department of Rheumatology and Immunology, Hannover Medical School, 30625 Hannover, Germany
- Sebastian R. Schulz
- Division of Molecular Immunology, Department of Internal Medicine 3, Friedrich-Alexander University of Erlangen-Nürnberg, 91054 Erlangen, Germany
- Hans-Martin Jäck
- Division of Molecular Immunology, Department of Internal Medicine 3, Friedrich-Alexander University of Erlangen-Nürnberg, 91054 Erlangen, Germany
- Georg M. N. Behrens
- Department of Rheumatology and Immunology, Hannover Medical School, 30625 Hannover, Germany
- Stefan Pöhlmann
- Infection Biology Unit, German Primate Center—Leibniz Institute for Primate Research, 37077 Göttingen, Germany
- Markus Hoffmann
- Infection Biology Unit, German Primate Center—Leibniz Institute for Primate Research, 37077 Göttingen, Germany
- DOI
- https://doi.org/10.3390/vaccines12050487
- Journal volume & issue
-
Vol. 12,
no. 5
p. 487
Abstract
Transmissibility and immune evasion of the recently emerged, highly mutated SARS-CoV-2 BA.2.87.1 are unknown. Here, we report that BA.2.87.1 efficiently enters human cells but is more sensitive to antibody-mediated neutralization than the currently dominating JN.1 variant. Acquisition of adaptive mutations might thus be needed for efficient spread in the population.
Keywords
