Biomedicines (Nov 2021)

Rodent Brain Pathology, Audiogenic Epilepsy

  • Irina B. Fedotova,
  • Natalia M. Surina,
  • Georgy M. Nikolaev,
  • Alexandre V. Revishchin,
  • Inga I. Poletaeva

DOI
https://doi.org/10.3390/biomedicines9111641
Journal volume & issue
Vol. 9, no. 11
p. 1641

Abstract

Read online

The review presents data which provides evidence for the internal relationship between the stages of rodent audiogenic seizures and post-ictal catalepsy with the general pattern of animal reaction to the dangerous stimuli and/or situation. The wild run stage of audiogenic seizure fit could be regarded as an intense panic reaction, and this view found support in numerous experimental data. The phenomenon of audiogenic epilepsy probably attracted the attention of physiologists as rodents are extremely sensitive to dangerous sound stimuli. The seizure proneness in this group shares common physiological characteristics and depends on animal genotype. This concept could be the new platform for the study of epileptogenesis mechanisms.

Keywords