Nature Communications (Apr 2020)

A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells

  • Masahiro Wakita,
  • Akiko Takahashi,
  • Osamu Sano,
  • Tze Mun Loo,
  • Yoshinori Imai,
  • Megumi Narukawa,
  • Hidehisa Iwata,
  • Tatsuyuki Matsudaira,
  • Shimpei Kawamoto,
  • Naoko Ohtani,
  • Tamotsu Yoshimori,
  • Eiji Hara

DOI
https://doi.org/10.1038/s41467-020-15719-6
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 13

Abstract

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Senescent cells can influence the tumour microenvironment by secreting immunomodulatory factors and are thus a therapeutic target. Here, the authors identify a compound that degrades BET leading to DNA damage and activation of autophagy and a reduction in tumour growth.