Clostridium difficile infection in the pediatric patients of an oncological hospital: cultivation of anaerobic intestinal flora and treatment

Abstract

In recent years, the number of infectious diseases caused by Clostridium difficile in the world has grown with a significant increase in relapses and mortality in patients, particularly among cancer patients in hospitals. An increase in the resistance of Clostridium difficile to first-line drugs, namely metronidazole and vancomycin, has also been observed and that makes the search for new methods of treatment and the prevention of this infection even more urgent. In this review, we analyze the recent data on the methods of the cultivation and isolation of the pure bacterial culture of Clostridium difficile and other anaerobic enteropathogens over the course of enterocolitis treatment with antimicrobial drugs in pediatric patients with oncopathology. Novel approaches to the therapy of this infection are discussed.