Nature Communications (Jun 2022)

The influence of Holliday junction sequence and dynamics on DNA crystal self-assembly

  • Chad R. Simmons,
  • Tara MacCulloch,
  • Miroslav Krepl,
  • Michael Matthies,
  • Alex Buchberger,
  • Ilyssa Crawford,
  • Jiří Šponer,
  • Petr Šulc,
  • Nicholas Stephanopoulos,
  • Hao Yan

DOI
https://doi.org/10.1038/s41467-022-30779-6
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 9

Abstract

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Engineered crystal architectures from DNA have become a foundational goal for nanotechnological precise arrangement. Here, the authors systematically investigate the structures of 36 immobile Holliday junction sequences and identify the features allowing the crystallisation of most of them, while 6 are considered fatal.