Natural polysaccharides regulate intestinal microbiota for inhibiting colorectal cancer
Lili Liu,
Yinan Li,
Xiaoting Zheng,
Rong Huang,
Xiaoli Huang,
Yonghui Zhao,
Wenjing Liu,
Yanli Lei,
Qiu Li,
Zhangfeng Zhong,
Ziyun Zhao
Affiliations
Lili Liu
University of Health and Rehabilitation Sciences (Qingdao Central Medical Group), Qingdao, 266000, China
Yinan Li
University of Health and Rehabilitation Sciences (Qingdao Central Medical Group), Qingdao, 266000, China
Xiaoting Zheng
Macao Centre for Research and Development in Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR, 999078, China
Rong Huang
Macao Centre for Research and Development in Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR, 999078, China; College of Chemistry and Pharmaceutical Sciences, National Joint Local Engineering Laboratory of Agricultural Bio-Pharmaceutical Laboratory, Qingdao, Agricultural University, Qingdao, 266109, China
Xiaoli Huang
College of Chemistry and Pharmaceutical Sciences, National Joint Local Engineering Laboratory of Agricultural Bio-Pharmaceutical Laboratory, Qingdao, Agricultural University, Qingdao, 266109, China
Yonghui Zhao
University of Health and Rehabilitation Sciences (Qingdao Central Medical Group), Qingdao, 266000, China
Wenjing Liu
College of Chemistry and Pharmaceutical Sciences, National Joint Local Engineering Laboratory of Agricultural Bio-Pharmaceutical Laboratory, Qingdao, Agricultural University, Qingdao, 266109, China
Yanli Lei
College of Chemistry and Pharmaceutical Sciences, National Joint Local Engineering Laboratory of Agricultural Bio-Pharmaceutical Laboratory, Qingdao, Agricultural University, Qingdao, 266109, China
Qiu Li
College of Chemistry and Pharmaceutical Sciences, National Joint Local Engineering Laboratory of Agricultural Bio-Pharmaceutical Laboratory, Qingdao, Agricultural University, Qingdao, 266109, China; Corresponding author.
Zhangfeng Zhong
Macao Centre for Research and Development in Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR, 999078, China; Corresponding author.
Ziyun Zhao
University of Health and Rehabilitation Sciences (Qingdao Central Medical Group), Qingdao, 266000, China; Corresponding author.
The gastrointestinal tract is an important part of the human immune system. The gut microbiome, which constitutes a major component of the gastrointestinal tract, plays a crucial role in maintaining normal physiological functions and influences the development, diagnosis, and immunotherapy of colorectal cancer (CRC). Natural polysaccharides can be extracted from animals, plants, and traditional Chinese medicines. They serve as an essential energy source for the gut microbiome, promoting probiotic proliferation and regulating the intestinal microecological balance. Moreover, polysaccharides exhibit anti-tumor effects due to their immune regulatory functions and low toxicity. This review focuses on discussing these anti-tumor effects in CRC, along with improving gut microbiome dysbiosis and regulating the tumor immune microenvironment, providing evidence for effective therapeutic strategies against CRC.
