Nature Communications (Mar 2020)

DJ-1 suppresses ferroptosis through preserving the activity of S-adenosyl homocysteine hydrolase

  • Ji Cao,
  • Xiaobing Chen,
  • Li Jiang,
  • Bin Lu,
  • Meng Yuan,
  • Difeng Zhu,
  • Hong Zhu,
  • Qiaojun He,
  • Bo Yang,
  • Meidan Ying

DOI
https://doi.org/10.1038/s41467-020-15109-y
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 15

Abstract

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DJ-1 protects cells from oxidative stress-induced cell death; however its role in ferroptosis is unclear. Here, the authors show that DJ-1 suppresses ferroptosis through the transsulfuration pathway to compensate for the depletion of intracellular cysteine when cystine import is inhibited.