Nature Communications (May 2022)
The genomic and transcriptional landscape of primary central nervous system lymphoma
- Josefine Radke,
- Naveed Ishaque,
- Randi Koll,
- Zuguang Gu,
- Elisa Schumann,
- Lina Sieverling,
- Sebastian Uhrig,
- Daniel Hübschmann,
- Umut H. Toprak,
- Cristina López,
- Xavier Pastor Hostench,
- Simone Borgoni,
- Dilafruz Juraeva,
- Fabienne Pritsch,
- Nagarajan Paramasivam,
- Gnana Prakash Balasubramanian,
- Matthias Schlesner,
- Shashwat Sahay,
- Marc Weniger,
- Debora Pehl,
- Helena Radbruch,
- Anja Osterloh,
- Agnieszka Korfel,
- Martin Misch,
- Julia Onken,
- Katharina Faust,
- Peter Vajkoczy,
- Dag Moskopp,
- Yawen Wang,
- Andreas Jödicke,
- Lorenz Trümper,
- Ioannis Anagnostopoulos,
- Dido Lenze,
- Ralf Küppers,
- Michael Hummel,
- Clemens A. Schmitt,
- Otmar D. Wiestler,
- Stephan Wolf,
- Andreas Unterberg,
- Roland Eils,
- Christel Herold-Mende,
- Benedikt Brors,
- ICGC MMML-Seq Consortium,
- Reiner Siebert,
- Stefan Wiemann,
- Frank L. Heppner
Affiliations
- Josefine Radke
- Department of Neuropathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health
- Naveed Ishaque
- Digital Health Center, Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin
- Randi Koll
- Department of Neuropathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health
- Zuguang Gu
- Molecular Precision Oncology Program, NCT Heidelberg
- Elisa Schumann
- Department of Neuropathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health
- Lina Sieverling
- Division of Applied Bioinformatics, German Cancer Research Center (DKFZ)
- Sebastian Uhrig
- Molecular Precision Oncology Program, NCT Heidelberg
- Daniel Hübschmann
- Molecular Precision Oncology Program, NCT Heidelberg
- Umut H. Toprak
- Division Neuroblastoma Genomics, German Cancer Research Center (DKFZ)
- Cristina López
- Institute of Human Genetics, Ulm University & Ulm University Medical Center
- Xavier Pastor Hostench
- Molecular Precision Oncology Program, NCT Heidelberg
- Simone Borgoni
- Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ)
- Dilafruz Juraeva
- Molecular Precision Oncology Program, NCT Heidelberg
- Fabienne Pritsch
- Department of Neuropathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health
- Nagarajan Paramasivam
- Molecular Precision Oncology Program, NCT Heidelberg
- Gnana Prakash Balasubramanian
- Hopp Children’s Cancer Center, NCT Heidelberg (KiTZ)
- Matthias Schlesner
- Bioinformatics and Omics Data Analytics, German Cancer Research Center (DKFZ)
- Shashwat Sahay
- Institute of Pathology, Universitätsmedizin Greifswald
- Marc Weniger
- Institute of Cell Biology (Cancer Research), Medical Faculty, University of Duisburg-Essen
- Debora Pehl
- Department of Neuropathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health
- Helena Radbruch
- Department of Neuropathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health
- Anja Osterloh
- Department of Neuropathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health
- Agnieszka Korfel
- Department of Hematology, Oncology and Cancer Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health
- Martin Misch
- Department of Neurosurgery, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health
- Julia Onken
- Department of Neurosurgery, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health
- Katharina Faust
- Department of Neurosurgery, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health
- Peter Vajkoczy
- Department of Neurosurgery, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health
- Dag Moskopp
- Department for Neurosurgery, Vivantes Klinikum im Friedrichshain
- Yawen Wang
- Department for Neurosurgery, Vivantes Klinikum im Friedrichshain
- Andreas Jödicke
- Department for Neurosurgery, Vivantes Klinikum Neukölln
- Lorenz Trümper
- Department of Hematology and Oncology, Georg-Augusts-University of Göttingen
- Ioannis Anagnostopoulos
- Department of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health
- Dido Lenze
- Department of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health
- Ralf Küppers
- Institute of Cell Biology (Cancer Research), Medical Faculty, University of Duisburg-Essen
- Michael Hummel
- Department of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health
- Clemens A. Schmitt
- Medical Department of Hematology and Oncology, Johannes Kepler University, Kepler Universitätsklinikum
- Otmar D. Wiestler
- German Cancer Research Center (DKFZ)
- Stephan Wolf
- Genomics and Proteomics Core Facility, German Cancer Research Center (DKFZ)
- Andreas Unterberg
- Department of Neurosurgery, University Hospital Heidelberg
- Roland Eils
- Digital Health Center, Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin
- Christel Herold-Mende
- Department of Neurosurgery, University Hospital Heidelberg
- Benedikt Brors
- Molecular Precision Oncology Program, NCT Heidelberg
- ICGC MMML-Seq Consortium
- Reiner Siebert
- Institute of Human Genetics, Ulm University & Ulm University Medical Center
- Stefan Wiemann
- German Cancer Consortium (DKTK)
- Frank L. Heppner
- Department of Neuropathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health
- DOI
- https://doi.org/10.1038/s41467-022-30050-y
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 20
Abstract
Primary lymphomas of the central nervous system (PCNSL) are defined as diffuse large B-cell lymphomas (DLBCL) confined to the CNS. Here, the authors complete whole genome sequencing and RNA-seq to characterize 51 PCNSLs, and find common mutations in immune pathways and upregulated TERT expression and find distinct pathway differences between DLBCL and other primary CNS lymphomas.
