New Polyenes from the Marine-Derived Fungus <i>Talaromyces cyanescens</i> with Anti-Neuroinflammatory and Cytotoxic Activities
Hee Jae Shin,
Cao Van Anh,
Duk-Yeon Cho,
Dong-Kug Choi,
Jong Soon Kang,
Phan Thi Hoai Trinh,
Byeoung-Kyu Choi,
Hwa-Sun Lee
Affiliations
Hee Jae Shin
Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 385 Haeyang-ro, Yeongdo-gu, Busan 49111, Korea
Cao Van Anh
Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 385 Haeyang-ro, Yeongdo-gu, Busan 49111, Korea
Duk-Yeon Cho
Department of Applied Life Science, Graduate school, BK21 Program, Konkuk University, Chungju 27478, Korea
Dong-Kug Choi
Department of Applied Life Science, Graduate school, BK21 Program, Konkuk University, Chungju 27478, Korea
Jong Soon Kang
Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanjiro, Cheongju 28116, Korea
Phan Thi Hoai Trinh
Department of Marine Biotechnology, Nhatrang Institute of Technology Research and Application, Vietnam Academy of Science and Technology, 02 Hung Vuong, Nha Trang 650000, Vietnam
Byeoung-Kyu Choi
Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 385 Haeyang-ro, Yeongdo-gu, Busan 49111, Korea
Hwa-Sun Lee
Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 385 Haeyang-ro, Yeongdo-gu, Busan 49111, Korea
Three new polyene compounds, talacyanols A–C (1–3), along with two known compounds, ramulosin (4) and eurothiocin A (5), were isolated from the marine fungus Talaromyces cyanescens derived from a seaweed Caulerpa sp. Structures of 1–5 were established by one-dimensional and two-dimensional (1D/2D) NMR, HR-ESIMS, and the modified Mosher’s methods, as well as comparison with previously reported literature data. All the compounds (1–5) were tested for their in vitro cytotoxic and anti-neuroinflammatory activities. Among them, 1 showed moderate cytotoxic activity against a panel of cancer cell lines (HCT-15, NUGC-3, NCI-H23, ACHN, PC-3, and MDA-MB-231) with GI50 values ranging from 44.4 to 91.6 μM, whereas compounds 2 and 5 exhibited anti-neuroinflammatory effect without cytotoxicity against all the tested cell lines.
