پزشکی بالینی ابن سینا (Mar 2003)
A Comparative Study of Trichomonas Vaginitis Treatment with Single and Seven Day Metronidazole Regimen
Abstract
Vaginitis is one of the most common genital tract infectious disease and the major cause of that is trichomonas vaginalis.In this prospective study, seven day therapeutic regimen was compared with single day therapeutic regimen and rate of cure and recurrence was accounted. 606 suspected women to trichomoniasis examined with wet mount. Trichomonas vaginalis was seen in 76 women. Randomisely, women and their partner were treated with seven day metronidazole (500 mg two times daily) and single day metronidazole (1 gr morning and evening) regimen. Every group composed of 38 women. Culture and wet mount was repeated 1 week and 1 month after treatment. Efficacy and recurrence and clinical cure rate of two regimens were compared. Two groups were not significantly different in terms of age, weight, education, follow up and last menstrual period. In the single day group, one patient missed. By use of Dorsee culture cure rate were 100% in seven day group and 97.3% in single day group (P=0.87). Recurrence rate were 2.6% and 5.4% in seven and single day regimens respectively. There were not significantly statistical difference between two groups (P= 0.5). Occurrence of side effects were not significantly different between two groups, but headache was observed in 21.6% and 7.9% of women in single day and seven day groups respectively. Single day regimen is recommended as an alternative therapeutic regimen in trichomoniasis. High efficacy, short therapeutic period and low cost are advantages of this regimen.
