Frontiers in Endocrinology (Nov 2023)

The causal relationship between sarcopenic obesity factors and benign prostate hyperplasia

  • Xuezhi Rao,
  • Xuezhi Rao,
  • Zhijie Xu,
  • Zhijie Xu,
  • Jingchun Zhang,
  • Jiaxiang Zhou,
  • Jian Huang,
  • Zhanhao Toh,
  • Ruwen Zheng,
  • Zhiyu Zhou,
  • Zhiyu Zhou

DOI
https://doi.org/10.3389/fendo.2023.1290639
Journal volume & issue
Vol. 14

Abstract

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BackgroundBoth benign prostatic hyperplasia (BPH) and sarcopenic obesity (SO) are common conditions among older adult/adults males. The prevalent lifestyle associated with SO is a significant risk factor for the development of BPH. Therefore, we investigated the causal relationship between SO factors and BPH.MethodThe instrumental variables for SO factors were selected using the inverse variance-weighted method, which served as the primary approach for Mendelian randomization analysis to assess the causal effect based on summary data derived from genome-wide association studies of BPH.ResultThe increase in BMR (OR = 1.248; 95% CI = (1.087, 1.432); P = 0.002) and ALM (OR = 1.126; 95% CI = (1.032, 1.228); P = 0.008) was found to be associated with an elevated risk of BPH. However, no genetic causality between fat-free mass distribution, muscle mass distribution, and BPH was observed.ConclusionOur findings indicate that a genetic causal association between BMR, ALM and BPH. BMR and ALM are risk factors for BPH. The decrease in BMR and ALM signified the onset and progression of SO, thus SO is a protective factor for BPH.

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