Nature Communications (Aug 2022)

Transcriptomic diversity in human medullary thymic epithelial cells

  • Jason A. Carter,
  • Léonie Strömich,
  • Matthew Peacey,
  • Sarah R. Chapin,
  • Lars Velten,
  • Lars M. Steinmetz,
  • Benedikt Brors,
  • Sheena Pinto,
  • Hannah V. Meyer

DOI
https://doi.org/10.1038/s41467-022-31750-1
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 15

Abstract

Read online

The thymus generates all T cells, including those that underly autoimmune diseases. Here, using deep sequencing, the authors profile human medullary thymic epithelial cells and establish a web portal to query their transcriptome, which may serve as a tool to help identify the drivers of autoimmunity.