Nature Communications (Nov 2021)

Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin

  • Jialiang S. Wang,
  • Tushar Kamath,
  • Courtney M. Mazur,
  • Fatemeh Mirzamohammadi,
  • Daniel Rotter,
  • Hironori Hojo,
  • Christian D. Castro,
  • Nicha Tokavanich,
  • Rushi Patel,
  • Nicolas Govea,
  • Tetsuya Enishi,
  • Yunshu Wu,
  • Janaina da Silva Martins,
  • Michael Bruce,
  • Daniel J. Brooks,
  • Mary L. Bouxsein,
  • Danielle Tokarz,
  • Charles P. Lin,
  • Abdul Abdul,
  • Evan Z. Macosko,
  • Melissa Fiscaletti,
  • Craig F. Munns,
  • Pearl Ryder,
  • Maria Kost-Alimova,
  • Patrick Byrne,
  • Beth Cimini,
  • Makoto Fujiwara,
  • Henry M. Kronenberg,
  • Marc N. Wein

DOI
https://doi.org/10.1038/s41467-021-26571-7
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 20

Abstract

Read online

The molecular circuitry that drives dendrite formation during osteocytogenesis remains poorly understood. Here the authors show that deletion of Sp7, a gene linked to rare and common skeletal disease, in mature osteoblasts and osteocytes causes severe defects in osteocyte dendrites.