Nature Communications (Nov 2019)

JASPer controls interphase histone H3S10 phosphorylation by chromosomal kinase JIL-1 in Drosophila

  • Christian Albig,
  • Chao Wang,
  • Geoffrey P. Dann,
  • Felix Wojcik,
  • Tamás Schauer,
  • Silke Krause,
  • Sylvain Maenner,
  • Weili Cai,
  • Yeran Li,
  • Jack Girton,
  • Tom W. Muir,
  • Jørgen Johansen,
  • Kristen M. Johansen,
  • Peter B. Becker,
  • Catherine Regnard

DOI
https://doi.org/10.1038/s41467-019-13174-6
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 17

Abstract

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The chromosomal kinase JIL-1 is responsible for interphase histone H3S10 phosphorylation and has been proposed to protect active chromatin from heterochromatinisation. Here, the authors show that JIL-1 is stabilized and anchored to active genes and telomeric transposons by JASPer, which binds to H3K36me3 nucleosomes via its PWWP domain.