Study the role of dyslipidemia in cases of neuropathy with type 2 diabetes mellitus

Abstract

Background Diabetic neuropathy is one of the most common neurological diseases. Dyslipidemia is very common in diabetic patients and thought to add to the effect of diabetes on peripheral nerves. Objectives To assess the effect of dyslipidemia on diabetic peripheral neuropathy among patients with type 2 diabetes mellitus. Patients and methods A total of 60 patients with peripheral diabetic polyneuropathy were included and divided into two groups: the first included 30 patients with diabetic neuropathy and dyslipidemia and the other 30 patients had diabetic neuropathy without dyslipidemia. Another 30 healthy volunteers were included as a control group. All were subjected to full history taking, clinical examination, laboratory investigations, and neurophysiological studies. Results Hypertension and smoking were significantly increased in cases when compared with controls. Regarding the severity of neuropathy, it was mild in seven (11.7%) patients, moderate in 34 (56.7%) patients, and severe in 19 (31.7%) patients. Neurophysiological studies of the studied populations revealed significant changes of both motor and sensory parameters in cases when compared with controls and in the group with dyslipidemia when compared with the group without dyslipidemia. In addition, there was a significant correlation between lipid profile and each of glycated hemoglobin, fasting and postprandial blood sugar, and different neurophysiological examinations. Conclusion Dyslipidemia added to the hazardous effect of diabetic neuropathy on neurophysiological studies. In addition, there was a significant correlation between lipid profile and changes in nerve conduction studies.

Keywords

• amplitude
• conduction velocity
• dyslipidemia
• nerve conduction studies
• neuropathy