Brain leptin reduces liver lipids by increasing hepatic triglyceride secretion and lowering lipogenesis

Martina Theresa Hackl; Clemens Fürnsinn; Christina Maria Schuh; Martin Krssak; Fabrizia Carli; Sara Guerra; Angelika Freudenthaler; Sabina Baumgartner-Parzer; Thomas H. Helbich; Anton Luger; Maximilian Zeyda; Amalia Gastaldelli; Christoph Buettner; Thomas Scherer

doi:10.1038/s41467-019-10684-1

Nature Communications (Jun 2019)

Brain leptin reduces liver lipids by increasing hepatic triglyceride secretion and lowering lipogenesis

Martina Theresa Hackl,
Clemens Fürnsinn,
Christina Maria Schuh,
Martin Krssak,
Fabrizia Carli,
Sara Guerra,
Angelika Freudenthaler,
Sabina Baumgartner-Parzer,
Thomas H. Helbich,
Anton Luger,
Maximilian Zeyda,
Amalia Gastaldelli,
Christoph Buettner,
Thomas Scherer

Affiliations

Martina Theresa Hackl: Department of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna
Clemens Fürnsinn: Department of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna
Christina Maria Schuh: Department of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna
Martin Krssak: Department of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna
Fabrizia Carli: Institute of Clinical Physiology, National Research Council
Sara Guerra: Institute of Clinical Physiology, National Research Council
Angelika Freudenthaler: Department of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna
Sabina Baumgartner-Parzer: Department of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna
Thomas H. Helbich: Department of Biomedical Imaging and Image-Guided Therapy, Division of Molecular and Gender Imaging, Medical University of Vienna
Anton Luger: Department of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna
Maximilian Zeyda: Department of Pediatrics and Adolescent Medicine, Medical University of Vienna
Amalia Gastaldelli: Institute of Clinical Physiology, National Research Council
Christoph Buettner: Departments of Medicine and Neuroscience, and Diabetes, Obesity and Metabolism Institute (DOMI), Icahn School of Medicine at Mt Sinai, One Gustave L. Levy Pl
Thomas Scherer: Department of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna

DOI: https://doi.org/10.1038/s41467-019-10684-1
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

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Obesity is associated with leptin resistance and rising blood leptin levels while central leptin exposure may be limited. Here, the authors show that brain leptin infusion reduces hepatic lipid content in rats by increasing hepatic VLDL secretion and lowering liver de novo lipogenesis via a vagal mechanism.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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