A double whammy! Rare occurrence of psoriasis vulgaris in a case of X-linked recessive ichthyosis

Abstract

Ichthyosis and psoriasis both are inherently considered as disorders of abnormal keratinization. X-linked recessive ichthyosis (XLRI) is a genetic disorder, while psoriasis is sporadic in most cases. The underlying pathophysiology for their occurrence in the same patient is not well understood but may be attributed to genetic modifications or epigenetics. We hereby report a case of a 14-year-old male child with psoriasis vulgaris in the setting of XLRI. To our best knowledge, it has not been reported in the English literature to date.

Keywords

• epigenetics
• genetic
• psoriasis vulgaris
• x-linked recessive ichthyosis