Viruses (Jul 2010)

Is there Emergence of Clinical HBV Resistance Under Long-Term HBV Combination Therapy? A Challenging Case Report

  • Jürgen Kurt Rockstroh,
  • Jan van Lunzen,
  • Stefan Schmiedel,
  • Hüseyin Sirma,
  • Christian Noah,
  • Knud Schewe,
  • Oliver Schildgen

DOI
https://doi.org/10.3390/v2081564
Journal volume & issue
Vol. 2, no. 8
pp. 1564 – 1570

Abstract

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A first case of clinical tenofovir (TDF) HBV resistance in an HIV/HBV coinfected patient who developed an acute flare of hepatitis B is reported. The clinical course was accompanied by signs of acute liver failure after being on successful HBV treatment with tenofovir and persistently undetectable HBV-DNA viral load for over five years.

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