A H2O2-activatable nanoprobe for diagnosing interstitial cystitis and liver ischemia-reperfusion injury via multispectral optoacoustic tomography and NIR-II fluorescent imaging

Junjie Chen; Longqi Chen; Yinglong Wu; Yichang Fang; Fang Zeng; Shuizhu Wu; Yanli Zhao

doi:10.1038/s41467-021-27233-4

Nature Communications (Nov 2021)

A H2O2-activatable nanoprobe for diagnosing interstitial cystitis and liver ischemia-reperfusion injury via multispectral optoacoustic tomography and NIR-II fluorescent imaging

Junjie Chen,
Longqi Chen,
Yinglong Wu,
Yichang Fang,
Fang Zeng,
Shuizhu Wu,
Yanli Zhao

Affiliations

Junjie Chen: Biomedical Division, State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, College of Materials Science and Engineering, South China University of Technology
Longqi Chen: Biomedical Division, State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, College of Materials Science and Engineering, South China University of Technology
Yinglong Wu: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University
Yichang Fang: Biomedical Division, State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, College of Materials Science and Engineering, South China University of Technology
Fang Zeng: Biomedical Division, State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, College of Materials Science and Engineering, South China University of Technology
Shuizhu Wu: Biomedical Division, State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, College of Materials Science and Engineering, South China University of Technology
Yanli Zhao: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University

DOI: https://doi.org/10.1038/s41467-021-27233-4
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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Fluorescent imaging in the second biological window has advantages for in vivo applications. Here, the authors synthesise a molecular nanoprobe which activates upon binding H2O2, generating both strong fluorescent NIR-II emission and ultrasound signal for multi-mode imaging of inflammatory diseases.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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