Uterine glands coordinate on-time embryo implantation and impact endometrial decidualization for pregnancy success

Abstract

The transcription factor FOXA2 is specifically expressed in uterine glands. Here, using two conditional FOXA2 knockout mouse models, the authors show that glandular epithelia of the endometrium are required for timely embryo implantation and subsequent endometrial decidualization during successful pregnancy establishment.