Tumor Biology (Jul 2017)

MiR-204/ZEB2 axis functions as key mediator for MALAT1-induced epithelial–mesenchymal transition in breast cancer

  • Yuzhou Wang,
  • Yijin Zhou,
  • Zhicheng Yang,
  • Baoying Chen,
  • Wennan Huang,
  • Yongyuan Liu,
  • Ying Zhang

DOI
https://doi.org/10.1177/1010428317690998
Journal volume & issue
Vol. 39

Abstract

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Long non-coding RNAs recently were identified as key mediators of cancer metastasis. This study provided evidence that long non-coding RNA MALAT1 was up-regulated in breast cancer tissues and cell lines. MALAT1 promoted cancer cell invasion through inducing epithelial–mesenchymal transition. Interestingly, we revealed there was a reciprocal repression between MALAT1 and miR-204. ZEB2 was identified as a downstream target of miR-204 and MALAT1 exerted its function mainly through the miR-204/ZEB2 axis. Our findings suggested that MALAT1 may serve as a new diagnostic biomarker and therapy target for breast cancer.