Plasminogen activators in acute management of thrombosis

Abstract

The paper focuses on the problem of intravascular thrombosis and the methods of its treatment. The data on haemostasis pathophysiology, which underlie the occurrence of acute ischemic events in humans, are presented, together with the data on the action mechanisms of fibrinolytic medications. The focus is on tenecteplase, as a modified agent which is more effective than the native tissue plasminogen activator or its closest derivatives.

Keywords

• fibrinolysis, thromboembolism, myocardial infarction, thrombosis, tenecteplase.