AMB Express (Jun 2022)

A canine-derived chimeric antibody with high neutralizing activity against canine parvovirus-2

  • Lixuan Zhou,
  • Hongchao Wu,
  • Mengmeng Du,
  • Huanhuan Song,
  • Ningning Huo,
  • Xiao Chen,
  • Xiaorui Su,
  • Weiguo Li,
  • Lulu Wang,
  • Jie Wang,
  • Baicheng Huang,
  • Feifei Tan,
  • Kegong Tian

DOI
https://doi.org/10.1186/s13568-022-01416-8
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 9

Abstract

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Key points A canine-derived chimeric MAb 11D9 was produced by CHO cell lines. The MAb 11D9 exhibited high HI and neutralization titers against new CPV-2 variants. The MAb 11D9 had a high therapeutic effect in beagles infected with the new CPV-2a variant.

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