Nature Communications (Feb 2021)
ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism
- Jie Li,
- Phillip M. Galbo,
- Weida Gong,
- Aaron J. Storey,
- Yi-Hsuan Tsai,
- Xufen Yu,
- Jeong Hyun Ahn,
- Yiran Guo,
- Samuel G. Mackintosh,
- Ricky D. Edmondson,
- Stephanie D. Byrum,
- Jason E. Farrar,
- Shenghui He,
- Ling Cai,
- Jian Jin,
- Alan J. Tackett,
- Deyou Zheng,
- Gang Greg Wang
Affiliations
- Jie Li
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine
- Phillip M. Galbo
- Department of Genetics, Albert Einstein College of Medicine
- Weida Gong
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine
- Aaron J. Storey
- Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences
- Yi-Hsuan Tsai
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine
- Xufen Yu
- Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Jeong Hyun Ahn
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine
- Yiran Guo
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine
- Samuel G. Mackintosh
- Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences
- Ricky D. Edmondson
- Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences
- Stephanie D. Byrum
- Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences
- Jason E. Farrar
- Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences and Arkansas Children’s Research Institute
- Shenghui He
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine
- Ling Cai
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine
- Jian Jin
- Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Alan J. Tackett
- Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences
- Deyou Zheng
- Department of Genetics, Albert Einstein College of Medicine
- Gang Greg Wang
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine
- DOI
- https://doi.org/10.1038/s41467-021-21357-3
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 18
Abstract
The fusion gene ZMYND11-MBTD1 (ZM) is present in a subgroup of patients with acute myeloid leukaemia (AML). Here, the authors show that ZM expression induces AML in a murine model though activating the NuA4/TIP60 histone acetyltransferase complex.
