EFFECT OF ALENDRONATE COMBINED WITH ALFACALCIDOL ON THE BIOLOGICAL STABILITY OF HIP JOINT ENDOPROSTHESIS IN PATIENTS WITH SYSTEMIC OSTEOPOROSIS

Abstract

In a comparative study we investigated the influence of a combination of alendronate and alfacalcidol on the dynamics of bone mass density (BMD) at the site attached to the femoral component of endoprosthesis in total hip replacement in patients with systemic osteoporosis. Evaluation of performance of pharmacotherapy in the postoperative period on osteoporosis, systemic osteoporosis, sustained BMD deficit at Gruen regions confirmed that the essential component of osteointegration at the «implant-bone» site during the period of physiological adaptive remodeling after arthroplasty in women suffering from systemic osteoporosis is the pharmacological correction of the intensity of bone resorption in post-operative period.

Keywords

• остеопороз
• эндопротезирование тазобедренного сустава
• алендронат
• альфакальцидол
• коррекция интенсивности резорбции и костеобразования