Association between perioperative platelet distribution width changes and postoperative acute kidney injury in patients with renal insufficiency: a retrospective study

Abstract

Abstract Background Acute kidney injury (AKI) is a major complication following cardiac surgery with a high incidence in those with existing kidney dysfunction. Platelet distribution width (PDW) reflects variability in platelet size and serves as an indicator of platelet activation. Recent investigations linked PDW changes to kidney pathology, suggesting its utility in identifying individuals at risk for AKI, thus necessitating exploration of its predictive value. Methods Patients with preoperative renal dysfunction [15 ≤ estimated glomerular filtration rate (eGFR) 0.05). Conclusions This study underscored perioperative PDW changes as a significant predictor of postoperative AKI in patients with renal insufficiency, highlighting its potential in refining risk stratification and management strategies. Clinical trial number Not applicable for this observational retrospective study.

Keywords

• Cardiac surgery
• Acute kidney injury
• Risk factors
• Platelet distribution width
• Renal function