Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration

Xin Ding; Jin Wang; Miaoxin Huang; Zhangpeng Chen; Jing Liu; Qipeng Zhang; Chenyu Zhang; Yang Xiang; Ke Zen; Liang Li

doi:10.1038/s41467-021-22301-1

Nature Communications (Apr 2021)

Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration

Xin Ding,
Jin Wang,
Miaoxin Huang,
Zhangpeng Chen,
Jing Liu,
Qipeng Zhang,
Chenyu Zhang,
Yang Xiang,
Ke Zen,
Liang Li

Affiliations

Xin Ding: Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy, Chinese Academy of Medical Sciences Research Unit of Extracellular RNA, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University
Jin Wang: Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy, Chinese Academy of Medical Sciences Research Unit of Extracellular RNA, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University
Miaoxin Huang: Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy, Chinese Academy of Medical Sciences Research Unit of Extracellular RNA, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University
Zhangpeng Chen: Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy, Chinese Academy of Medical Sciences Research Unit of Extracellular RNA, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University
Jing Liu: Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy, Chinese Academy of Medical Sciences Research Unit of Extracellular RNA, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University
Qipeng Zhang: Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy, Chinese Academy of Medical Sciences Research Unit of Extracellular RNA, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University
Chenyu Zhang: Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy, Chinese Academy of Medical Sciences Research Unit of Extracellular RNA, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University
Yang Xiang: Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy, Chinese Academy of Medical Sciences Research Unit of Extracellular RNA, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University
Ke Zen: Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy, Chinese Academy of Medical Sciences Research Unit of Extracellular RNA, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University
Liang Li: Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy, Chinese Academy of Medical Sciences Research Unit of Extracellular RNA, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University

DOI: https://doi.org/10.1038/s41467-021-22301-1
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 17

Abstract

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Microglial SIRPα regulates synaptic pruning during development. Its role in neurodegeneration is unclear. Here, the authors show microglial SIRPα declines in the model of Alzheimer’s disease, leading to excessive microglia mediated synapse elimination as well as impaired cognitive function.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal