Capture Efficiency of Magnetically Labeled Particles Traveling Through an Intracranial Aneurysm

Abstract

Cell manipulation using external magnetic fields has been proposed to accelerate the neck reendothelization of saccular unruptured stented intracranial aneurysms. This work presents a computational fluid dynamics (CFD) model of a Saccular Brain Aneurysm that incorporates a helicoidal stent. An Eulerian-Lagrangian model implemented in ANSYS-Fluent is used to simulate the hemodynamics in the aneurysm. In silico studies have been conducted to describe the incidence of the magnetic field direction, frequency and amplitude on the blood hemodynamics and particle capture efficiency, when an external magnetic field is used to trap magnetically labeled particles traveling through the aneurysm. It is found that the magnetic field direction affects the particle concentration in the target region. Simulation results show that the highest particle capture efficiency is obtained with a 1T magnetic field amplitude in an open bore MRI scanner, when a permanent magnet is used.

Keywords

• endothelization
• particle manipulation
• computational fluid dynamics
• magnetohydrodynamics