Фармакокинетика и Фармакодинамика (Feb 2017)

Pharmacokinetic study of prolonged release capsules of mebeverine

  • A. L. Khokhlov,
  • Yu. A. Dzhurko,
  • L. N. Shitov,
  • I. I. Yaichkov,
  • A. M. Shitova,
  • L. A. Khozova,
  • A. E. Miroshnikov

Journal volume & issue
Vol. 0, no. 1
pp. 57 – 62

Abstract

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Pharmacokinetic study of prolonged release capsules of mebeverine was carried out on 24 volunteers. It is known that the drug substance is completely metabolized due to first-pass effect. Therefore, pharmacokinetic parameters of the main metabolites -mebeverine acid and desmethyl mebeverine acid were measured. Bioanalytical method was developed to measurement of concentrations of these metabolites in blood plasma by using HPLC-MS/MS.

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