Lugdunin amplifies innate immune responses in the skin in synergy with host- and microbiota-derived factors

Katharina Bitschar; Birgit Sauer; Jule Focken; Hanna Dehmer; Sonja Moos; Martin Konnerth; Nadine A. Schilling; Stephanie Grond; Hubert Kalbacher; Florian C. Kurschus; Friedrich Götz; Bernhard Krismer; Andreas Peschel; Birgit Schittek

doi:10.1038/s41467-019-10646-7

Nature Communications (Jun 2019)

Lugdunin amplifies innate immune responses in the skin in synergy with host- and microbiota-derived factors

Katharina Bitschar,
Birgit Sauer,
Jule Focken,
Hanna Dehmer,
Sonja Moos,
Martin Konnerth,
Nadine A. Schilling,
Stephanie Grond,
Hubert Kalbacher,
Florian C. Kurschus,
Friedrich Götz,
Bernhard Krismer,
Andreas Peschel,
Birgit Schittek

Affiliations

Katharina Bitschar: Department of Dermatology, University of Tübingen
Birgit Sauer: Department of Dermatology, University of Tübingen
Jule Focken: Department of Dermatology, University of Tübingen
Hanna Dehmer: Department of Dermatology, University of Tübingen
Sonja Moos: Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz
Martin Konnerth: Institute of Organic Chemistry, University of Tübingen
Nadine A. Schilling: Institute of Organic Chemistry, University of Tübingen
Stephanie Grond: Institute of Organic Chemistry, University of Tübingen
Hubert Kalbacher: Interfaculty Institute of Biochemistry, University of Tübingen
Florian C. Kurschus: Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz
Friedrich Götz: Interfaculty Institute of Microbiology and Infection Medicine, Microbial Genetics, University of Tübingen
Bernhard Krismer: Interfaculty Institute of Microbiology and Infection Medicine, Infection Biology, University of Tübingen
Andreas Peschel: Interfaculty Institute of Microbiology and Infection Medicine, Infection Biology, University of Tübingen
Birgit Schittek: Department of Dermatology, University of Tübingen

DOI: https://doi.org/10.1038/s41467-019-10646-7
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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Lugdunin is a peptide antibiotic produced by the skin commensal Staphylococcus lugdunensis. Here, the authors show that lugdunin reduces Staphylococcus aureus colonization in human keratinocytes and mouse skin by inducing the expression of human LL-37 and recruitment of monocytes and neutrophils.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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